Numberlys quizlet3/19/2023 ![]() ![]() Amino acid residues are organized as a sequence of repeating tripeptide units Gly-X-Y, where X is often proline and Y is often Hyp. Smaller amounts of 3-hdyroxyl proline, and 5-hydroxylysyl residues are also present Primary structure of a typical collagen protein has a distinctive amino acid composition (Gly about one third, Pro and 4-hydroxyl proline about 15-30%) Contains 3 parallel left handed helical polypeptides (2 identical ones alpha1 and an additional chain that differs slightly in its composition alpha2) that are super twisted about each other in a right handed rope like twist to form the triple helical structure Wool is extensible and can be stretched to twice its length as the alpha helices stretch, breaking the weak interactions between neighboring helices while the covalent disulfide bonds resist breakage and return the fiber to its original state Though they don't know what it is, they decide to protect this unique little thing - which isn't easy. Hardest and toughest alpha-keratins (horns of rhinos) has 18% of cysteine residues involved in disulfide bonds In a concrete and metal city, five best friends discover something they've never seen before - a tiny sprout. Are classified as hard/soft according to high/low sulfur content (ex: horns/nails are hard keratins while skin is soft) The strength of these fibrous proteins in thus enhanced by the covalent crosslinks formed by the disulfide bonds between polypeptide chains which make them one of the strongest biological materials and has various use in mammals from predatory claws to hair for warmth Microfibrils associate to macrofibrils (mammalian hair consists of layers of dead cells each of which is packed with parallel microfibrils) Protofilaments dimerize to form protofibrils which tetramerize to form microfibrils In higher order structure, many dimers associate to form protofilaments linked by disulfide bonds It contains a 7 residue pseudo repeat (a-b-c-d-e-f-g) where a and d residues are hydrophobic which are responsible for the association of the two sub units The two helices are also linked via covalent disulfide bonds formed by neighboring cysteine residues which confer its hardiness ![]() The Numberlys is an epic homage to Fritz Lang's Metropolis, but for kids. With Joe Bluhm, Calvin O'Neal Jr., Tyler Schatz. The R groups of the hydrophobic amino acid residues in one helix interact with the hydrophobic residues in the other helix in a regular interlocking pattern via van der Waals forces that amplifies its strength country split into multi-member constituencies and electorate numberly rank candidates by preference - can rank as many as they wish. The Numberlys: Directed by William Joyce, Brandon Oldenburg. ![]() The helical path of the super twist is left handed, opposite in sense to the alpha helix Is a dimer that consists of two right-handed alpha helices in parallel and intertwined to form a super twisted coiled coil ![]()
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